Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular …
FQ Liang, BF Godley - Experimental eye research, 2003 - Elsevier
Oxidative stress is believed to contribute to the pathogenesis of many diseases, including
age-related macular degeneration (AMD). Although the vision loss of AMD results from
photoreceptor damage in the central retina, the initial pathogenesis involves degeneration of
RPE cells. Evidence from a variety of studies suggests that RPE cells are susceptible to
oxidative damage. Mitochondrial DNA (mtDNA) is particularly prone to oxidative damage
compared to nuclear DNA (nDNA). Using the quantitative PCR assay, a powerful tool to …
age-related macular degeneration (AMD). Although the vision loss of AMD results from
photoreceptor damage in the central retina, the initial pathogenesis involves degeneration of
RPE cells. Evidence from a variety of studies suggests that RPE cells are susceptible to
oxidative damage. Mitochondrial DNA (mtDNA) is particularly prone to oxidative damage
compared to nuclear DNA (nDNA). Using the quantitative PCR assay, a powerful tool to …