Role of Prostaglandin Receptor EP1in the Spinal Dorsal Horn in Carrageenan-induced Inflammatory Pain
Y Nakayama, K Omote, A Namiki - The Journal of the American …, 2002 - pubs.asahq.org
Background Prostaglandin E2 (PGE2) and the receptor for PGE2 (EP receptor) are key
factors contributing to the generation of hyperalgesia caused by inflammation. The current
study was designed to investigate the roles of PGE2 and EP1 receptors in the spinal cord in
the development and maintenance of inflammatory pain, using behavioral, microdialysis,
and intracellular calcium ion concentration ([Ca2+] i) assays. Methods Inflammation was
induced by an injection of carrageenan into the plantar surface of the rat hind paw. The …
factors contributing to the generation of hyperalgesia caused by inflammation. The current
study was designed to investigate the roles of PGE2 and EP1 receptors in the spinal cord in
the development and maintenance of inflammatory pain, using behavioral, microdialysis,
and intracellular calcium ion concentration ([Ca2+] i) assays. Methods Inflammation was
induced by an injection of carrageenan into the plantar surface of the rat hind paw. The …