Involvement of p38 MAP kinase during iron chelator-mediated apoptotic cell death
BS Kim, KH Yoon, HM Oh, EY Choi, SW Kim… - Cellular …, 2002 - Elsevier
Iron is an essential element for the neoplastic cell growth, and iron chelators have been
tested for their potential anti-proliferative and cytotoxic effects. To determine the mechanism
of cell death induced by iron chelators, we explored the pathways of the three structurally
related mitogen-activated protein (MAP) kinase subfamilies during apoptosis induced by
iron chelators. We report that the chelator deferoxamine (DFO) strongly activates both p38
MAP kinase and extracellular signal-regulated kinase (ERK) at an early stage of incubation …
tested for their potential anti-proliferative and cytotoxic effects. To determine the mechanism
of cell death induced by iron chelators, we explored the pathways of the three structurally
related mitogen-activated protein (MAP) kinase subfamilies during apoptosis induced by
iron chelators. We report that the chelator deferoxamine (DFO) strongly activates both p38
MAP kinase and extracellular signal-regulated kinase (ERK) at an early stage of incubation …