[HTML][HTML] Expression of multiple genes regulating cell cycle and apoptosis in differentiating hematopoietic cells is dependent on iron
O Alcantara, M Kalidas, I Baltathakis, DH Boldt - Experimental hematology, 2001 - Elsevier
OBJECTIVE: Iron plays critical roles in many biological processes including hematopoietic
cell growth and differentiation. Iron is essential for the differentiation of HL-60 promonocytes.
HL-60 cells stimulated with phorbol myristate acetate (PMA) undergo G1/S phase cell-cycle
arrest and differentiate to monocyte/macrophages. With iron deprivation, PMA-induced HL-
60 cells bypass differentiation and undergo apoptosis. To investigate the molecular basis
underlying this observation, we used commercially available gene microarrays to evaluate …
cell growth and differentiation. Iron is essential for the differentiation of HL-60 promonocytes.
HL-60 cells stimulated with phorbol myristate acetate (PMA) undergo G1/S phase cell-cycle
arrest and differentiate to monocyte/macrophages. With iron deprivation, PMA-induced HL-
60 cells bypass differentiation and undergo apoptosis. To investigate the molecular basis
underlying this observation, we used commercially available gene microarrays to evaluate …