Heme oxygenase-1 in renal injury: conclusions of studies in humans and animal models
YS Kanwar - Kidney international, 2001 - kidney-international.org
Heme, a ferroprotoporphyrin, derived from various demonstrated that cytoprotection against
heme protein–hemoproteins, is catabolized by the enzyme heme oxy- induced toxicity can
occur even when HO-1 is induced genase [1–4]. It degrades heme to biliverdin, which is by
agents such as an endotoxin [10] or by the administrametabolized by biliverdin reductase to
bilirubin. The ca- tion of heterologous antibody as in nephrotoxic serum tabolism of heme to
biliverdin by heme oxygenase re- nephritis [11]. More recently, they confirmed the role of …
heme protein–hemoproteins, is catabolized by the enzyme heme oxy- induced toxicity can
occur even when HO-1 is induced genase [1–4]. It degrades heme to biliverdin, which is by
agents such as an endotoxin [10] or by the administrametabolized by biliverdin reductase to
bilirubin. The ca- tion of heterologous antibody as in nephrotoxic serum tabolism of heme to
biliverdin by heme oxygenase re- nephritis [11]. More recently, they confirmed the role of …