Low molecular weight iron-binding factor from mammalian tissue that potentiates bacterial growth.
RL Jones, CM Peterson, RW Grady… - The Journal of …, 1980 - rupress.org
RL Jones, CM Peterson, RW Grady, A Cerami
The Journal of experimental medicine, 1980•rupress.orgA low molecular weight, iron-binding factor was isolated from horse liver. This host-
associated iron transfer factor (HAITF) is capable of binding iron and stimulating bacterial
growth by promoting iron uptake into bacteria. Also, when injected into infected animals,
HAITF increases the virulence of bacterial infections. HAITF bioactivity is ubiquitous in
animal tissues and present in serum. It is proposed that HAITF is a factor that inadvertently
plays a role in the host-parasite competition for iron.
associated iron transfer factor (HAITF) is capable of binding iron and stimulating bacterial
growth by promoting iron uptake into bacteria. Also, when injected into infected animals,
HAITF increases the virulence of bacterial infections. HAITF bioactivity is ubiquitous in
animal tissues and present in serum. It is proposed that HAITF is a factor that inadvertently
plays a role in the host-parasite competition for iron.
A low molecular weight, iron-binding factor was isolated from horse liver. This host-associated iron transfer factor (HAITF) is capable of binding iron and stimulating bacterial growth by promoting iron uptake into bacteria. Also, when injected into infected animals, HAITF increases the virulence of bacterial infections. HAITF bioactivity is ubiquitous in animal tissues and present in serum. It is proposed that HAITF is a factor that inadvertently plays a role in the host-parasite competition for iron.
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