Transferrin receptor gene expression and transferrin-bound iron uptake are increased during postischemic rat liver reperfusion
L Tacchini, DF Poli, A Bernelli-Zazzera, G Cairo - Hepatology, 2002 - journals.lww.com
Iron-catalyzed production of reactive oxygen species is a cause of liver injury after
ischemia/reperfusion (I/R). The aim of the present study was to address the regulation of
transferrin receptor (TfR), which mediates cellular iron uptake, during I/R. The molecular
mechanisms controlling TfR gene expression in vivo during I/R of rat liver were investigated
by molecular biology procedures. We also analyzed transferrin-bound iron uptake into
surviving liver slices. Increased amounts of TfR protein and messenger RNA (mRNA) were …
ischemia/reperfusion (I/R). The aim of the present study was to address the regulation of
transferrin receptor (TfR), which mediates cellular iron uptake, during I/R. The molecular
mechanisms controlling TfR gene expression in vivo during I/R of rat liver were investigated
by molecular biology procedures. We also analyzed transferrin-bound iron uptake into
surviving liver slices. Increased amounts of TfR protein and messenger RNA (mRNA) were …