[HTML][HTML] Increased hepatic VLDL secretion, lipogenesis, and SREBP-1 expression in the corpulent JCR: LA-cp rat
MB Elam, HG Wilcox, LM Cagen, X Deng… - Journal of Lipid …, 2001 - ASBMB
The corpulent JCR: LA-cp rat (cp/cp) is a useful model for study of the metabolic
consequences of obesity and hyperinsulinemia. To assess the effect of hyperinsulinemia on
VLDL secretion in this model, we measured rates of secretion of VLDL in perfused livers
derived from cp/cp rats and their lean littermates. Livers of cp/cp rats secreted significantly
greater amounts of VLDL triglyceride and apolipoprotein, compared with lean littermates.
The content of apoB, apoE, and apoCs in both perfusate and plasma VLDL was greater in …
consequences of obesity and hyperinsulinemia. To assess the effect of hyperinsulinemia on
VLDL secretion in this model, we measured rates of secretion of VLDL in perfused livers
derived from cp/cp rats and their lean littermates. Livers of cp/cp rats secreted significantly
greater amounts of VLDL triglyceride and apolipoprotein, compared with lean littermates.
The content of apoB, apoE, and apoCs in both perfusate and plasma VLDL was greater in …