Obesity, diabetes, and neoplasia in yellow Avy/‐ mice: ectopic expression of the agouti gene
TT Yen, AM Gill, LG Frigeri, GS Barsh… - The FASEB …, 1994 - Wiley Online Library
TT Yen, AM Gill, LG Frigeri, GS Barsh, GL Wolff
The FASEB journal, 1994•Wiley Online LibraryThe viable yellow Avy mutation results in a mottled yellow mouse that is obese, slightly
larger than its nonyellow sibs, and more susceptible to tumor formation in those tissues
sensitized by the strain genome. The mutation exhibits variable expressivity resulting in a
continuum of coat color phenotypes, from clear yellow to pseudoagouti. The mouse agouti
protein is a paracrine signaling molecule that induces hair follicle melanocytes to switch
from the synthesis of black pigment to yellow pigment. Molecular cloning studies indicate …
larger than its nonyellow sibs, and more susceptible to tumor formation in those tissues
sensitized by the strain genome. The mutation exhibits variable expressivity resulting in a
continuum of coat color phenotypes, from clear yellow to pseudoagouti. The mouse agouti
protein is a paracrine signaling molecule that induces hair follicle melanocytes to switch
from the synthesis of black pigment to yellow pigment. Molecular cloning studies indicate …
The viable yellow Avy mutation results in a mottled yellow mouse that is obese, slightly larger than its nonyellow sibs, and more susceptible to tumor formation in those tissues sensitized by the strain genome. The mutation exhibits variable expressivity resulting in a continuum of coat color phenotypes, from clear yellow to pseudoagouti. The mouse agouti protein is a paracrine signaling molecule that induces hair follicle melanocytes to switch from the synthesis of black pigment to yellow pigment. Molecular cloning studies indicate that the obesity and growth effects of the Avy mutation result from ectopic expression of the normal agouti gene product. This review seeks to summarize the current state of knowledge regarding the obesity, stimulation of somatic growth, and enhancement of tumor formation caused by the Avy mutation, and to interpret these pleiotropic effects in terms of the normal function of the agouti protein.—Yen, T. T., Gill, A. M., Frigeri, L. G., Barsh, G. S., and Wolff, G. L. Obesity, diabetes, and neoplasia in yellow Avy/‐ mice: ectopic expression of the agouti gene. FASEB J. 8: 479‐488; 1994.
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