Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia.
B Angelin, K Einarsson, K Hellström, B Leijd - Journal of lipid research, 1978 - ASBMB
Previous studies conducted under basal conditions have suggested a linkage between the
formation of plasma triglyceride and the degradation of cholesterol to bile acids. To further
examine this relationship, plasma endogenous triglyceride kinetics were determined using
[(3) H] glycerol in 26 hyperlipidemic subjects before and during stimulated (cholestyramine
treatment) and inhibited (chenodeoxycholic acid treatment) bile acid synthesis. All patients
with hyperlipoproteinemia (HLP) type II (n= 9) treated with cholestyramine (12 g daily for 2-4 …
formation of plasma triglyceride and the degradation of cholesterol to bile acids. To further
examine this relationship, plasma endogenous triglyceride kinetics were determined using
[(3) H] glycerol in 26 hyperlipidemic subjects before and during stimulated (cholestyramine
treatment) and inhibited (chenodeoxycholic acid treatment) bile acid synthesis. All patients
with hyperlipoproteinemia (HLP) type II (n= 9) treated with cholestyramine (12 g daily for 2-4 …