Publisher Summary This chapter focuses on class I-deficient mice, including studies of T cell
recognition, natural killer (NK) cell responses, lymphocyte development, transplantation,
protective immune responses, and immunopathological reactions. Major histocompatibility
complex (MHC)-encoded molecules play critical roles in the protective immune response, in
various immunopathological reactions, and in reactions against transplanted tissues. The
central function of class I MHC molecules appears to be the presentation on the cell surface …