Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members
W Krek, DM Livingston, S Shirodkar - Science, 1993 - science.org
W Krek, DM Livingston, S Shirodkar
Science, 1993•science.orgThe E2F family of transcription factors functions in the control of the mammalian cell cycle.
Here it is shown that two family members, E2F-1 and DP-1, form specific heterodimers in
vivo, a process that enhances DNA binding, transactivation, and the binding of the
retinoblastoma gene product. These results suggest that heterodimerization regulates E2F
function and contributes to cell cycle control.
Here it is shown that two family members, E2F-1 and DP-1, form specific heterodimers in
vivo, a process that enhances DNA binding, transactivation, and the binding of the
retinoblastoma gene product. These results suggest that heterodimerization regulates E2F
function and contributes to cell cycle control.
The E2F family of transcription factors functions in the control of the mammalian cell cycle. Here it is shown that two family members, E2F-1 and DP-1, form specific heterodimers in vivo, a process that enhances DNA binding, transactivation, and the binding of the retinoblastoma gene product. These results suggest that heterodimerization regulates E2F function and contributes to cell cycle control.
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