Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21–q23 and is associated with a common polymorphism in LMNA …
C Weyer, JK Wolford, RL Hanson, JE Foley… - Molecular genetics and …, 2001 - Elsevier
Large subcutaneous abdominal adipocyte size (sc abd. AS) is associated with insulin
resistance and predicts type 2 diabetes in Pima Indians. Because type 2 diabetes is familial,
we aimed to determine whether mean sc abd. AS is also familial and if so, to identify
chromosomal regions linked to this measure. Body composition (hydrodensitometry) and
mean sc abd. AS (fat biopsy) were measured in 295 Pima Indians (179 with normal, 80 with
impaired, and 36 with diabetic glucose tolerance) representing 164 nuclear families. Mean …
resistance and predicts type 2 diabetes in Pima Indians. Because type 2 diabetes is familial,
we aimed to determine whether mean sc abd. AS is also familial and if so, to identify
chromosomal regions linked to this measure. Body composition (hydrodensitometry) and
mean sc abd. AS (fat biopsy) were measured in 295 Pima Indians (179 with normal, 80 with
impaired, and 36 with diabetic glucose tolerance) representing 164 nuclear families. Mean …