The phenomenon of acute phase (AP) response can be reproduced in vitro using cultured
cells of hepatic origin by stimulation with the crude supernatant of activated monocytes
(MoCM). Several monocyte-derived factors have been identified which might be
responsible, alone or in combination, for the induction of AP response, but recently the
attention has been focused on interleukin 6 (IL-6). We have previously shown that part of the
AP response consists of the increase in the rate of transcription of the AP genes. Here we …