[HTML][HTML] Poly (ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1
V Schreiber, JC Amé, P Dollé, I Schultz… - Journal of Biological …, 2002 - ASBMB
The DNA damage dependence of poly (ADP-ribose) polymerase-2 (PARP-2) activity is
suggestive of its implication in genome surveillance and protection. Here we show that the
PARP-2 gene, mainly expressed in actively dividing tissues follows, but to a smaller extent,
that of PARP-1 during mouse development. We found that PARP-2 and PARP-1 homo-and
heterodimerize; the interacting interfaces, sites of reciprocal modification, have been
mapped. PARP-2 was also found to interact with three other proteins involved in the base …
suggestive of its implication in genome surveillance and protection. Here we show that the
PARP-2 gene, mainly expressed in actively dividing tissues follows, but to a smaller extent,
that of PARP-1 during mouse development. We found that PARP-2 and PARP-1 homo-and
heterodimerize; the interacting interfaces, sites of reciprocal modification, have been
mapped. PARP-2 was also found to interact with three other proteins involved in the base …