Control of immune pathology by regulatory T cells
D Mason, F Powrie - Current opinion in immunology, 1998 - Elsevier
D Mason, F Powrie
Current opinion in immunology, 1998•ElsevierThere is now compelling evidence that immune responses for both foreign and self antigens
are downregulated by T cells that are specialised for this function; these are known as
regulatory T (T reg) cells. This review describes progress in the characterisation of the T reg
cells that mediate both mucosal tolerance and tolerance to self antigens. The recent work on
the antigen specificity, generation and mode of action of T reg cells is also reviewed.
are downregulated by T cells that are specialised for this function; these are known as
regulatory T (T reg) cells. This review describes progress in the characterisation of the T reg
cells that mediate both mucosal tolerance and tolerance to self antigens. The recent work on
the antigen specificity, generation and mode of action of T reg cells is also reviewed.
There is now compelling evidence that immune responses for both foreign and self antigens are downregulated by T cells that are specialised for this function; these are known as regulatory T (T reg) cells. This review describes progress in the characterisation of the T reg cells that mediate both mucosal tolerance and tolerance to self antigens. The recent work on the antigen specificity, generation and mode of action of T reg cells is also reviewed.
Elsevier
