Bone-Marrow Transplantation: (Second of Two Parts)
ED Thomas, R Storb, RA Clift, A Fefer… - … England Journal of …, 1975 - Mass Medical Soc
ED Thomas, R Storb, RA Clift, A Fefer, FL Johnson, PE Neiman, KG Lerner, H Glucksberg…
New England Journal of Medicine, 1975•Mass Medical SocCurrent Problems Success or Failure of Marrow Engraftment and Marrow-Graft Rejection A
review of the literature of human marrow transplantation before 1967 showed a high
incidence of complete failure of engraftment. 113 Failure of initial allogeneic engraftment is
no longer a major problem. Excluding five patients who died too soon to be evaluated, 33 of
34 grafts in patients with aplastic anemia were successfully established, and 63 of 68 in
acute leukemia were successful. The quantity of marrow infused ranged from 1.1 to 10.9× …
review of the literature of human marrow transplantation before 1967 showed a high
incidence of complete failure of engraftment. 113 Failure of initial allogeneic engraftment is
no longer a major problem. Excluding five patients who died too soon to be evaluated, 33 of
34 grafts in patients with aplastic anemia were successfully established, and 63 of 68 in
acute leukemia were successful. The quantity of marrow infused ranged from 1.1 to 10.9× …
Current Problems
Success or Failure of Marrow Engraftment and Marrow-Graft Rejection
A review of the literature of human marrow transplantation before 1967 showed a high incidence of complete failure of engraftment.113 Failure of initial allogeneic engraftment is no longer a major problem. Excluding five patients who died too soon to be evaluated, 33 of 34 grafts in patients with aplastic anemia were successfully established, and 63 of 68 in acute leukemia were successful. The quantity of marrow infused ranged from 1.1 to 10.9 × 108 per kilogram of recipient body weight (Table 4). Despite this range . . .
The New England Journal Of Medicine