Sensitivity to intravenous injections of histamine and serotonin in inbred mouse strains
NM Vaz, CM de Souza, MM Hornbrook… - … Archives of Allergy and …, 1977 - karger.com
NM Vaz, CM de Souza, MM Hornbrook, DG Hanson, NR Lynch
International Archives of Allergy and Immunology, 1977•karger.comA large panel of inbred strains of mice and some of their F1 hybrids were tested on their
sensitivity to the hemoconcentrating effects of intravenous injections of histamine alone,
serotonin alone, or histamine-serotonin mixtures. Major differences in susceptibility were
observed. Crosses and backcrosses were made between susceptible (SJL/J) and less
susceptible (RF/J, C57BL/6J) strains; it was found that the sensitivity to vasoactive amines is,
at least partially, inheritable.
sensitivity to the hemoconcentrating effects of intravenous injections of histamine alone,
serotonin alone, or histamine-serotonin mixtures. Major differences in susceptibility were
observed. Crosses and backcrosses were made between susceptible (SJL/J) and less
susceptible (RF/J, C57BL/6J) strains; it was found that the sensitivity to vasoactive amines is,
at least partially, inheritable.
Abstract
A large panel of inbred strains of mice and some of their F1 hybrids were tested on their sensitivity to the hemoconcentrating effects of intravenous injections of histamine alone, serotonin alone, or histamine-serotonin mixtures. Major differences in susceptibility were observed. Crosses and backcrosses were made between susceptible (SJL/J) and less susceptible (RF/J, C57BL/6J) strains; it was found that the sensitivity to vasoactive amines is, at least partially, inheritable.
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