p53 expression in pituitary adenomas and carcinomas: correlation with invasiveness and tumor growth fractions
K Thapar, BW Scheithauer, K Kovacs… - …, 1996 - journals.lww.com
Abstract ALTHOUGH MOST PITUITARY tumors are well differentiated, histologically benign
neoplasms, their clinical behavior is known to vary greatly. These lesions are relentlessly
aggressive in some instances yet biologically indolent in others, but these prognostically
relevant differences in behavior are not reflected in their histopathological appearance. As a
means of identifying intrinsically aggressive pituitary tumors, we evaluated 70 pituitary
adenomas and 7 primary pituitary carcinomas for their expression of the p53 gene product, a …
neoplasms, their clinical behavior is known to vary greatly. These lesions are relentlessly
aggressive in some instances yet biologically indolent in others, but these prognostically
relevant differences in behavior are not reflected in their histopathological appearance. As a
means of identifying intrinsically aggressive pituitary tumors, we evaluated 70 pituitary
adenomas and 7 primary pituitary carcinomas for their expression of the p53 gene product, a …