Migration of helper T-lymphocyte subsets into inflamed tissues
NW Lukacs - Journal of allergy and clinical immunology, 2000 - Elsevier
The localization of lymphocytes to specific tissues is a finely regulated event that has key
implications in the development of chronic allergic inflammation that is associated with
allergic rhinitis, atopic dermatitis, and asthma. Key players in the tissue localization of
lymphocytes and other allergic effector cells include cellular adhesion molecules and
chemokines. The expression or activation pattern of these proinflammatory mediators
appears to depend, in part, on the local cytokine milieu. For instance, the TH1 phenotype is …
implications in the development of chronic allergic inflammation that is associated with
allergic rhinitis, atopic dermatitis, and asthma. Key players in the tissue localization of
lymphocytes and other allergic effector cells include cellular adhesion molecules and
chemokines. The expression or activation pattern of these proinflammatory mediators
appears to depend, in part, on the local cytokine milieu. For instance, the TH1 phenotype is …
