Inorganic phosphate is essential for skeletal mineralization and for multiple cellular
functions, including glycolysis, gluconeogenesis, DNA synthesis, RNA synthesis, cellular
protein phosphorylation, and intracellular regulatory roles. Normally, dietary intake, intestinal
absorption, and renal tubular filtration and reabsorption determine phosphate homeostasis.
Dietary phosphate (800–1600 mg/day) is primarily absorbed in the jejunum and ileum in
proportion to food phosphate content. 84 If phosphate intake is very low, vitamin D …