OBJECTIVE: This paper reviews the current views of the pathogenesis of airway
eosinophilic inflammation and airway hyperresponsiveness (AHR) in allergic asthma based
on mouse models of the disease. The reader will also encounter new treatment strategies
that have arisen as this knowledge is applied in practice. DATA SOURCES: MEDLINE
searches were conducted with key words asthma, mouse model, and murine. Additional
articles were identified from references in articles and book chapters. STUDY SELECTION …