[HTML][HTML] Inhibition of interleukin-4-and CD40-induced IgE germline gene promoter activity by 2′-aminoethoxy-modified triplex-forming oligonucleotides
Elevated levels of IgE are intimately associated with a number of allergic diseases, such as
allergic rhinitis or asthma. Therefore, prevention of IgE production in human B-cells
represents an attractive therapeutic target. IL-4-induced IgE germline gene transcription
represents a crucial early step during IgE isotype switch differentiation. Gene induction is
orchestrated by the coordinated action of the transcription factors STAT6 (signal transducer
and activator of transcription), NF-κB, PU. 1, and C/EBP. This study shows that 2 …
allergic rhinitis or asthma. Therefore, prevention of IgE production in human B-cells
represents an attractive therapeutic target. IL-4-induced IgE germline gene transcription
represents a crucial early step during IgE isotype switch differentiation. Gene induction is
orchestrated by the coordinated action of the transcription factors STAT6 (signal transducer
and activator of transcription), NF-κB, PU. 1, and C/EBP. This study shows that 2 …
