Triple helix formation by oligonucleotides on DNA extended to the physiological pH range
TJ Povsic, PB Dervan - Journal of the american chemical society, 1989 - ACS Publications
TJ Povsic, PB Dervan
Journal of the american chemical society, 1989•ACS PublicationsFigure 2.(Top) Oligonucleotide 1-6 constructed from dcoxyribonucleotidc phosphoramidites
containing cytosine (C), 5-mcthylcytosinc (m5C). uridine (U), thymidine (T), 5-bromouridine
(Br5U), and thy-midinc-EDTA (T*). 7 (Bottom) Coarse resolution patternfor cleavage of
plasmid DNA (4.06 kbp) by oligonucleotide-EDTA 1-6 with sim-plified model of triplehelical
complex between the Hoogsteen-bound oligonucleotide (X5U/Y5C) and a 15 basepair
single site.
containing cytosine (C), 5-mcthylcytosinc (m5C). uridine (U), thymidine (T), 5-bromouridine
(Br5U), and thy-midinc-EDTA (T*). 7 (Bottom) Coarse resolution patternfor cleavage of
plasmid DNA (4.06 kbp) by oligonucleotide-EDTA 1-6 with sim-plified model of triplehelical
complex between the Hoogsteen-bound oligonucleotide (X5U/Y5C) and a 15 basepair
single site.
Figure 2.(Top) Oligonucleotide 1-6 constructed from dcoxyribonucleotidc phosphoramidites containing cytosine (C), 5-mcthylcytosinc (m5C). uridine (U), thymidine (T), 5-bromouridine (Br5U), and thy-midinc-EDTA (T*). 7 (Bottom) Coarse resolution patternfor cleavage of plasmid DNA (4.06 kbp) by oligonucleotide-EDTA 1-6 with sim-plified model of triplehelical complex between the Hoogsteen-bound oligonucleotide (X5U/Y5C) and a 15 basepair single site.
ACS Publications