Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin)
J Tian, M Karin - Journal of Biological Chemistry, 1999 - ASBMB
Cellular calcium (Ca 2+) and the Ca 2+-binding protein calmodulin (CaM) regulate the
activities of Ca 2+/CaM-dependent protein kinases and protein phosphatase 2B
(calcineurin). Functional interactions between CaM kinases and mitogen-activated protein
(MAP) kinases were described. In this report, we describe cross-talk between calcineurin
and mitogen-activated protein kinase signaling. Calcineurin was found to specifically down-
regulate the transcriptional activity of transcription factor Elk1, following stimulation of this …
activities of Ca 2+/CaM-dependent protein kinases and protein phosphatase 2B
(calcineurin). Functional interactions between CaM kinases and mitogen-activated protein
(MAP) kinases were described. In this report, we describe cross-talk between calcineurin
and mitogen-activated protein kinase signaling. Calcineurin was found to specifically down-
regulate the transcriptional activity of transcription factor Elk1, following stimulation of this …
