In vivo oxygen-17 nuclear magnetic resonance for the estimation of cerebral blood flow and oxygen consumption
T Arai, K Mori, S Nakao, K Watanabe, K Kito… - Biochemical and …, 1991 - Elsevier
T Arai, K Mori, S Nakao, K Watanabe, K Kito, M Aoki, H Mori, S Morikawa, T Inubushi
Biochemical and biophysical research communications, 1991•ElsevierTo explore the feasibility of in vivo 17 O NMR for the estimation of cerebral blood flow and
oxygen consumption, in vivo 17 O NMR spectroscopy and imaging were employed in animal
models. In the spectroscopy, the changes in the 17 O NMR signal intensity after the injection
of H 2 17 O and the inhalation of 17 O 2 gas were obtained every 4 seconds with sufficient
signal-to-noise ratios for the quantification of cerebral blood flow and oxygen consumption.
In the imaging, although the time and spatial resolutions were insufficient for the …
oxygen consumption, in vivo 17 O NMR spectroscopy and imaging were employed in animal
models. In the spectroscopy, the changes in the 17 O NMR signal intensity after the injection
of H 2 17 O and the inhalation of 17 O 2 gas were obtained every 4 seconds with sufficient
signal-to-noise ratios for the quantification of cerebral blood flow and oxygen consumption.
In the imaging, although the time and spatial resolutions were insufficient for the …
Abstract
To explore the feasibility of in vivo17O NMR for the estimation of cerebral blood flow and oxygen consumption, in vivo17O NMR spectroscopy and imaging were employed in animal models. In the spectroscopy, the changes in the 17O NMR signal intensity after the injection of H217O and the inhalation of 17O2 gas were obtained every 4 seconds with sufficient signal-to-noise ratios for the quantification of cerebral blood flow and oxygen consumption. In the imaging, although the time and spatial resolutions were insufficient for the quantification of H217O, 17O NMR images of rabbit brain could be obtained, indicating that it is possible to map cerebral blood flow and oxygen consumption by 17O NMR imaging.
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