Effect of the brain constituent anandamide, a cannabinoid receptor agonist, on the hypothalamo-pituitary-adrenal axis in the rat
J Weidenfeld, S Feldman, R Mechoulam - Neuroendocrinology, 1994 - karger.com
J Weidenfeld, S Feldman, R Mechoulam
Neuroendocrinology, 1994•karger.comAnandamide (arachidonylethanolamide), an endogenous ligand of the cannabinoid
receptor, was recently isolated from porcine brain. We report here for the first time on the
effect of this ligand on the hypothalamopituitary adrenal (HPA) axis in comparison to that of
the plant cannabinoid Δ9-tetrahydrocannabinol (THC). Intracerebroventricular injection of
anandamide or THC (50 or 150 µg/rat) increased significantly the serum levels of ACTH and
corticosterone in a dose-dependent manner and caused a pronounced depletion of CRF-41 …
receptor, was recently isolated from porcine brain. We report here for the first time on the
effect of this ligand on the hypothalamopituitary adrenal (HPA) axis in comparison to that of
the plant cannabinoid Δ9-tetrahydrocannabinol (THC). Intracerebroventricular injection of
anandamide or THC (50 or 150 µg/rat) increased significantly the serum levels of ACTH and
corticosterone in a dose-dependent manner and caused a pronounced depletion of CRF-41 …
Abstract
Anandamide (arachidonylethanolamide), an endogenous ligand of the cannabinoid receptor, was recently isolated from porcine brain. We report here for the first time on the effect of this ligand on the hypothalamopituitary adrenal (HPA) axis in comparison to that of the plant cannabinoid Δ9-tetrahydrocannabinol (THC). Intracerebroventricular injection of anandamide or THC (50 or 150 µg/rat) increased significantly the serum levels of ACTH and corticosterone in a dose-dependent manner and caused a pronounced depletion of CRF-41 in the median eminence. These data suggest that anandamide parallels THC in activating the HPA axis via mediation of a central mechanism which involves the secretion of CRF-41.
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