Expression of basic fibroblast growth factor in synovial tissue from patients with rheumatoid arthritis and degenerative joint disease.
Z Qu, XN Huang, P Ahmadi, J Andresevic… - … ; a journal of technical …, 1995 - europepmc.org
Z Qu, XN Huang, P Ahmadi, J Andresevic, SR Planck, CE Hart, JT Rosenbaum
Laboratory investigation; a journal of technical methods and pathology, 1995•europepmc.orgBackground Recent studies have implicated polypeptide growth factors in the development
of rheumatoid arthritis (RA), which is characterized by synoviocyte hyperplasia and
neovascularization. One such polypeptide, basic fibroblast growth factor (bFGF), is of
particular interest because of its potent mitogenic and angiogenic activities. We have
previously reported that cultured human synoviocytes synthesize and bind bFGF and also
proliferate in response to it (1). Recently, we found a close association between increased …
of rheumatoid arthritis (RA), which is characterized by synoviocyte hyperplasia and
neovascularization. One such polypeptide, basic fibroblast growth factor (bFGF), is of
particular interest because of its potent mitogenic and angiogenic activities. We have
previously reported that cultured human synoviocytes synthesize and bind bFGF and also
proliferate in response to it (1). Recently, we found a close association between increased …
Background
Recent studies have implicated polypeptide growth factors in the development of rheumatoid arthritis (RA), which is characterized by synoviocyte hyperplasia and neovascularization. One such polypeptide, basic fibroblast growth factor (bFGF), is of particular interest because of its potent mitogenic and angiogenic activities. We have previously reported that cultured human synoviocytes synthesize and bind bFGF and also proliferate in response to it (1). Recently, we found a close association between increased bFGF expression and destructive changes in arthritic joints from rats (2). Now we extend our study by detecting in vivo expression of bFGF in human synovial tissues obtained from patients with RA.
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