Suppression by cyclosporin A of murine T-cell-mediated immunity against viruses in vivo and in vitro
AW Huegin, A Cerny, H Hengartner… - Cellular immunology, 1985 - Elsevier
The immunosuppressive effect of Cyclosporin A on T-cell-mediated antiviral immune
responses was examined. When administered intraperitoneally CS-A abrogated anti-
vaccinia virus, anti-lymphocytic choriomeningitis virus (LCMV), and anti-vesicular stomatitis
virus (VSV) T-cell responses in a dose-dependent fashion. Usually 50–60 mg/kg were
efficient in suppressing primary T-cell responses completely. In contrast, 10–20 mg/kg often
enhanced T-cell responses significantly when compared with controls. Suppression was …
responses was examined. When administered intraperitoneally CS-A abrogated anti-
vaccinia virus, anti-lymphocytic choriomeningitis virus (LCMV), and anti-vesicular stomatitis
virus (VSV) T-cell responses in a dose-dependent fashion. Usually 50–60 mg/kg were
efficient in suppressing primary T-cell responses completely. In contrast, 10–20 mg/kg often
enhanced T-cell responses significantly when compared with controls. Suppression was …
