[HTML][HTML] Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein …
PJ Moos, K Edes, P Cassidy, E Massuda… - Journal of Biological …, 2003 - ASBMB
Tumor suppressor p53 exhibits an enigmatic phenotype in cells exposed to electrophilic,
cyclopentenone prostaglandins of the A and J series. Namely, cells harboring a wild-type
p53 gene accumulate p53 protein that is conformationally and functionally impaired. This
occurs via an unknown molecular mechanism. We report that electrophilic cyclopentenone
prostaglandins covalently modify and inhibit thioredoxin reductase, a selenoprotein that
governs p53 and other redox-sensitive transcription factors. This mechanism accounts fully …
cyclopentenone prostaglandins of the A and J series. Namely, cells harboring a wild-type
p53 gene accumulate p53 protein that is conformationally and functionally impaired. This
occurs via an unknown molecular mechanism. We report that electrophilic cyclopentenone
prostaglandins covalently modify and inhibit thioredoxin reductase, a selenoprotein that
governs p53 and other redox-sensitive transcription factors. This mechanism accounts fully …
