[HTML][HTML] Differential localization of 5-and 15-lipoxygenases to the nuclear envelope in RAW macrophages
P Christmas, JW Fox, SR Ursino… - Journal of Biological …, 1999 - ASBMB
Leukotriene formation is initiated in myeloid cells by an increase in intracellular calcium and
translocation of 5-lipoxygenase from the cytoplasm to the nuclear envelope where it can
utilize arachidonic acid. Monocyte-macrophages and eosinophils also express 15-
lipoxygenase, which converts arachidonic acid to 15 (S)-hydroxyeicosatetraenoic acid.
Enhanced green fluorescent 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) fusion
proteins were expressed in the cytoplasm of RAW 264.7 macrophages. Only 5-lipoxygenase …
translocation of 5-lipoxygenase from the cytoplasm to the nuclear envelope where it can
utilize arachidonic acid. Monocyte-macrophages and eosinophils also express 15-
lipoxygenase, which converts arachidonic acid to 15 (S)-hydroxyeicosatetraenoic acid.
Enhanced green fluorescent 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) fusion
proteins were expressed in the cytoplasm of RAW 264.7 macrophages. Only 5-lipoxygenase …
