Active conservation of noncoding sequences revealed by three-way species comparisons
Genome research, 2000•genome.cshlp.org
Human and mouse genomic sequence comparisons are being increasingly used to search
for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA
comparison studies have discovered numerous conserved noncoding sequences of which
only a fraction has been functionally investigated A question therefore remains as to whether
most of these noncoding sequences are conserved because of functional constraints or are
the result of a lack of divergence time.[The sequence data described in this paper have been …
for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA
comparison studies have discovered numerous conserved noncoding sequences of which
only a fraction has been functionally investigated A question therefore remains as to whether
most of these noncoding sequences are conserved because of functional constraints or are
the result of a lack of divergence time.[The sequence data described in this paper have been …
Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.
[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF276990.]
genome.cshlp.org
