Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre‐eclampsia
F Lyall, IA Greer, F Boswell… - BJOG: An International …, 1997 - Wiley Online Library
F Lyall, IA Greer, F Boswell, R Fleming
BJOG: An International Journal of Obstetrics & Gynaecology, 1997•Wiley Online LibraryObjective To determine whether vascular endothelial growth factor (VEGF) concentrations
are altered in pre‐eclampsia. Design Serum was prepared from peripheral venous blood
and stored at− 70° C. Serum VEGF concentrations were measured by ELISA. Setting
University of Glasgow Department of Obstetrics and Gynaecology, Royal Infirmary, Glasgow.
Participants Twenty‐two healthy nonpregnant volunteer women, 34 normal pregnant women
and 34 women with pre‐eclampsia were studied. Results Serum concentrations of VEGF …
are altered in pre‐eclampsia. Design Serum was prepared from peripheral venous blood
and stored at− 70° C. Serum VEGF concentrations were measured by ELISA. Setting
University of Glasgow Department of Obstetrics and Gynaecology, Royal Infirmary, Glasgow.
Participants Twenty‐two healthy nonpregnant volunteer women, 34 normal pregnant women
and 34 women with pre‐eclampsia were studied. Results Serum concentrations of VEGF …
Objective To determine whether vascular endothelial growth factor (VEGF) concentrations are altered in pre‐eclampsia.
Design Serum was prepared from peripheral venous blood and stored at −70°C. Serum VEGF concentrations were measured by ELISA.
Setting University of Glasgow Department of Obstetrics and Gynaecology, Royal Infirmary, Glasgow.
Participants Twenty‐two healthy nonpregnant volunteer women, 34 normal pregnant women and 34 women with pre‐eclampsia were studied.
Results Serum concentrations of VEGF were significantly lower in normal pregnant women (median value 12.89 pg/mL) than in nonpregnant women (median value 166 pg/mL; P < 0.0001). In pre‐eclampsia VEGF concentrations were significantly lower (median value 2.34 pg/mL) than normal pregnancies (P < 0.0001). Postpartum concentrations of VEGF in the group complicated by pre‐eclampsia (median value 76.42 pg/mL) were not significantly different from nonpregnant values (P= 0.2).
Conclusions Our results show that serum concentrations of VEGF are suppressed in pregnancy and further reduced in pre‐eclampsia. Further studies to elucidate the mechanisms which lead to a reduction in VEGF concentrations may provide new clues to the aetiology of this disorder.
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