[HTML][HTML] Release and complex formation of soluble VEGFR-1 from endothelial cells and biological fluids
C Hornig, B Barleon, S Ahmad, P Vuorela… - Laboratory …, 2000 - Elsevier
One of the key molecules promoting angiogenesis is the endothelial cell-specific mitogen,
vascular endothelial growth factor (VEGF or VEGF-A), which acts through two high-affinity
receptor tyrosine kinases (VEGFR), VEGFR-1 (or Flt-1) and VEGFR-2 (or KDR/Flk-1). It was
shown before that a soluble variant of VEGFR-1 (sVEGFR-1) can be generated by
differential splicing of the flt-1 mRNA. This soluble receptor is an antagonist to VEGF action,
reducing the level of free, active VEGF-A, and therefore, plays a pivotal role in the …
vascular endothelial growth factor (VEGF or VEGF-A), which acts through two high-affinity
receptor tyrosine kinases (VEGFR), VEGFR-1 (or Flt-1) and VEGFR-2 (or KDR/Flk-1). It was
shown before that a soluble variant of VEGFR-1 (sVEGFR-1) can be generated by
differential splicing of the flt-1 mRNA. This soluble receptor is an antagonist to VEGF action,
reducing the level of free, active VEGF-A, and therefore, plays a pivotal role in the …