Protein–DNA Interactions in Interferon-γ Signaling
C Park, C Schindler - Methods, 1998 - Elsevier
C Park, C Schindler
Methods, 1998•ElsevierThe ability to rapidly activate new genes is essential for the biological effects mediated by
IFN-γ. Studies directed at understanding how these genes are induced by this ligand led to
the identification of the STAT family of transcription factors. STATs are rapidly activated at the
receptor, whereupon they translocate to the nucleus and bind to a unique enhancer found in
the promoter of target genes. The ability to identify this IFN-γ response element and the
proteins that bind it was critical for the elucidation of this pathway. These techniques are the …
IFN-γ. Studies directed at understanding how these genes are induced by this ligand led to
the identification of the STAT family of transcription factors. STATs are rapidly activated at the
receptor, whereupon they translocate to the nucleus and bind to a unique enhancer found in
the promoter of target genes. The ability to identify this IFN-γ response element and the
proteins that bind it was critical for the elucidation of this pathway. These techniques are the …
The ability to rapidly activate new genes is essential for the biological effects mediated by IFN-γ. Studies directed at understanding how these genes are induced by this ligand led to the identification of the STAT family of transcription factors. STATs are rapidly activated at the receptor, whereupon they translocate to the nucleus and bind to a unique enhancer found in the promoter of target genes. The ability to identify this IFN-γ response element and the proteins that bind it was critical for the elucidation of this pathway. These techniques are the focus of this review.
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