[HTML][HTML] Cytosolic tyrosine dephosphorylation of STAT5: potential role of SHP-2 in STAT5 regulation
CL Yu, YJ Jin, SJ Burakoff - Journal of Biological Chemistry, 2000 - ASBMB
STAT5, a member of the signal transducers and activators of transcription (STATs), is
important in modulating T cell functions through interleukin-2 (IL-2) receptors. Like other
STAT proteins, STAT5 undergoes a rapid activation and inactivation cycle upon cytokine
stimulation. Tyrosine phosphorylation and dephosphorylation are critical in regulating
STAT5 activity. A number of protein tyrosine kinases have been shown to phosphorylate
STAT5; however, the phosphatases responsible for STAT5 dephosphorylation remain …
important in modulating T cell functions through interleukin-2 (IL-2) receptors. Like other
STAT proteins, STAT5 undergoes a rapid activation and inactivation cycle upon cytokine
stimulation. Tyrosine phosphorylation and dephosphorylation are critical in regulating
STAT5 activity. A number of protein tyrosine kinases have been shown to phosphorylate
STAT5; however, the phosphatases responsible for STAT5 dephosphorylation remain …