Hydroxyurea: mechanism of action
WN Fishbein, PP Carbone - Science, 1963 - science.org
WN Fishbein, PP Carbone
Science, 1963•science.orgAcetohydroxamic acid has been identified, by paper chromatography, in the blood of three
patients with chronic myelogenous leukemia on hydroxyurea therapy. This suggests that the
drug is hydrolyzed yielding hyroxylamine, which then cleaves thioesters, in particular acetyl-
coenzyme A.
patients with chronic myelogenous leukemia on hydroxyurea therapy. This suggests that the
drug is hydrolyzed yielding hyroxylamine, which then cleaves thioesters, in particular acetyl-
coenzyme A.
Acetohydroxamic acid has been identified, by paper chromatography, in the blood of three patients with chronic myelogenous leukemia on hydroxyurea therapy. This suggests that the drug is hydrolyzed yielding hyroxylamine, which then cleaves thioesters, in particular acetyl-coenzyme A.
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