[HTML][HTML] Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor α convertase
J Schlöndorff, L Lum, CP Blobel - Journal of Biological Chemistry, 2001 - ASBMB
A number of structurally and functionally diverse membrane proteins are released from the
plasma membrane in a process termed protein ectodomain shedding. Ectodomain shedding
may activate or inactivate a substrate or change its properties, such as converting a
juxtacrine into a paracrine signaling molecule. Here we have characterized the activities
involved in protein ectodomain shedding of the tumor necrosis factor family member
TRANCE/OPGL in different cell types. The criteria used to evaluate these activities include …
plasma membrane in a process termed protein ectodomain shedding. Ectodomain shedding
may activate or inactivate a substrate or change its properties, such as converting a
juxtacrine into a paracrine signaling molecule. Here we have characterized the activities
involved in protein ectodomain shedding of the tumor necrosis factor family member
TRANCE/OPGL in different cell types. The criteria used to evaluate these activities include …
