Insulin-like growth factor binding protein-1 binds to placental cytotrophoblast α5β1 integrin and inhibits cytotrophoblast invasion into decidualized endometrial stromal …
JC Irwin, LC Giudice - Growth Hormone & IGF Research, 1998 - Elsevier
Insulin-like growth factor binding protein-1 (IGFBP-1) can bind to the α5β1 integrin and
stimulate cellularmigration in Chinese hamster ovary (CHO) cells. IGFBP-1 is a major
product of the endometrium of pregnancy (decidua), and may interact with invading
cytotrophoblasts expressing α5β1 integrin to modulate their invasion. The present study
investigated IGFBP-1 interaction with cytotrophoblast α5β1 integrin, and its effects on
trophoblast attachment to fibronectin and invasion into decidualized endometrial stromal cell …
stimulate cellularmigration in Chinese hamster ovary (CHO) cells. IGFBP-1 is a major
product of the endometrium of pregnancy (decidua), and may interact with invading
cytotrophoblasts expressing α5β1 integrin to modulate their invasion. The present study
investigated IGFBP-1 interaction with cytotrophoblast α5β1 integrin, and its effects on
trophoblast attachment to fibronectin and invasion into decidualized endometrial stromal cell …
