Technique and results of hyperthermic isolated hepatic perfusion with tumor necrosis factor and melphalan for the treatment of unresectable hepatic malignancies
SK Libutti, DL Bartlett, DL Fraker… - Journal of the American …, 2000 - journals.lww.com
Background: For a variety of histologies, the liver represents the only or the dominant site of
metastatic disease. Regional treatment of the liver has the theoretic advantage of
maximizing drug delivery while minimizing systemic toxicity. This article describes the
technique of isolated hepatic perfusion using tumor necrosis factor and melphalan under
conditions of moderate hyperthermia for the treatment of unresectable liver tumors. Study
Design: Fifty patients with biopsy-proved unresectable primary or metastatic cancer to the …
metastatic disease. Regional treatment of the liver has the theoretic advantage of
maximizing drug delivery while minimizing systemic toxicity. This article describes the
technique of isolated hepatic perfusion using tumor necrosis factor and melphalan under
conditions of moderate hyperthermia for the treatment of unresectable liver tumors. Study
Design: Fifty patients with biopsy-proved unresectable primary or metastatic cancer to the …
