The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of
cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water,
forming aquated species that react with nucleophilic sites in cellular macromolecules. The
presence of the cisplatin adducts in DNA is thought to trigger cell cycle arrest and apoptosis.
Knowledge of the mechanism of action of cisplatin has improved our understanding of
resistance. Decerased intracellular concentration due to decreased drug uptake, increased …