Mitochondria and apoptosis
RA Gottlieb - Neurosignals, 2001 - karger.com
Neurosignals, 2001•karger.com
Apoptosis is a coordinated sequence of events culminating in the death of the cell. Many of
these biochemical processes are regulated by the mitochondria, including the release of
proapoptotic molecules in addition to the caspase-activating cofactor, cytochrome c. Pro-and
antiapoptotic members of the Bcl-2 family regulate mitochondrial participation in cell death.
Current models explaining cytochrome c release are discussed in light of mitochondrial
structure and physiology.
these biochemical processes are regulated by the mitochondria, including the release of
proapoptotic molecules in addition to the caspase-activating cofactor, cytochrome c. Pro-and
antiapoptotic members of the Bcl-2 family regulate mitochondrial participation in cell death.
Current models explaining cytochrome c release are discussed in light of mitochondrial
structure and physiology.
Abstract
Apoptosis is a coordinated sequence of events culminating in the death of the cell. Many of these biochemical processes are regulated by the mitochondria, including the release of proapoptotic molecules in addition to the caspase-activating cofactor, cytochrome c. Pro- and antiapoptotic members of the Bcl-2 family regulate mitochondrial participation in cell death. Current models explaining cytochrome c release are discussed in light of mitochondrial structure and physiology.
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