The biosynthesis of deoxyribonucleotides is catalyzed by ribonucleotide reductase in both
mammalian and bacterial cells. The enzyme is subject to a complicated allosteric control
which influences both its overall activity and its substrate specificity. Experiments with
mammalian cells in tissue culture aim at a correlation between in vitro data and results
obtained in vivo. Determinations of deoxynucleoside triphosphate pools were made during
normal growth of different cell lines, in parasynchronous cell cultures, and after addition and …