S-Adenosylhomocysteine Hydrolase Is an Adenosine-Binding Protein: a Target for Adenosine Toxicity
MS Hershfield, NM Krodich - Science, 1978 - science.org
MS Hershfield, NM Krodich
Science, 1978•science.orgWhen adenosine deaminase activity is inhibited, low concentrations of adenosine are toxic
to human lymphoblast mutants that are unable to convert adenosine to intracellular
nucleotides. In order to identify the mediator of this cytotoxicity, we searched for a
cytoplasmic protein capable of binding adenosine with high affinity. Such a protein was
identified in extracts of human lymphoblasts and placenta as the enzyme S-
adenosylhomocysteine hydrolase.
to human lymphoblast mutants that are unable to convert adenosine to intracellular
nucleotides. In order to identify the mediator of this cytotoxicity, we searched for a
cytoplasmic protein capable of binding adenosine with high affinity. Such a protein was
identified in extracts of human lymphoblasts and placenta as the enzyme S-
adenosylhomocysteine hydrolase.
When adenosine deaminase activity is inhibited, low concentrations of adenosine are toxic to human lymphoblast mutants that are unable to convert adenosine to intracellular nucleotides. In order to identify the mediator of this cytotoxicity, we searched for a cytoplasmic protein capable of binding adenosine with high affinity. Such a protein was identified in extracts of human lymphoblasts and placenta as the enzyme S-adenosylhomocysteine hydrolase.
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