HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2
M Metzler, V Legendre-Guillemin, L Gan… - Journal of Biological …, 2001 - ASBMB
Polyglutamine expansion in huntingtin is the underlying mutation leading to
neurodegeneration in Huntington disease. This mutation influences the interaction of
huntingtin with different proteins, including huntingtin-interacting protein 1 (HIP1), in which
affinity to bind to mutant huntingtin is profoundly reduced. Here we demonstrate that HIP1
colocalizes with markers of clathrin-mediated endocytosis in neuronal cells and is highly
enriched on clathrin-coated vesicles (CCVs) purified from brain homogenates. HIP1 binds to …
neurodegeneration in Huntington disease. This mutation influences the interaction of
huntingtin with different proteins, including huntingtin-interacting protein 1 (HIP1), in which
affinity to bind to mutant huntingtin is profoundly reduced. Here we demonstrate that HIP1
colocalizes with markers of clathrin-mediated endocytosis in neuronal cells and is highly
enriched on clathrin-coated vesicles (CCVs) purified from brain homogenates. HIP1 binds to …
