A non-sense mutation in Cd36 gene is associated with protection from severe malaria
The Lancet, 2001•thelancet.com
We sought genetic evidence for the importance of host-parasite interactions involving CD36
in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the
influence of this mutation on the outcome of malaria infection in 693 African children with
severe malaria and a similar number of ethnically matched controls. We showed that
heterozygosity for this mutation is associated with protection from severe disease (OR 0· 74,
95% CI 0· 55–0· 99; p= 0036). These findings suggest that this Cd36 mutation might have a …
in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the
influence of this mutation on the outcome of malaria infection in 693 African children with
severe malaria and a similar number of ethnically matched controls. We showed that
heterozygosity for this mutation is associated with protection from severe disease (OR 0· 74,
95% CI 0· 55–0· 99; p= 0036). These findings suggest that this Cd36 mutation might have a …
Summary
We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0·74, 95% CI 0·55–0·99; p=0036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.
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