Perforin-dependent cytolytic responses in β2-microglobulin-deficient mice
MJ Smyth, MB Snook - Cellular immunology, 1999 - Elsevier
The ability of β2-microglobulin-deficient mice (B6. β2μo) mice to reject syngeneic and major
histocompatability (MHC) class I-deficient tumor grafts was examined with a view to
determining residual cytotoxic activities that exist in these mice. In particular, the cytotoxic
activities of NK cells and CD8+ cytotoxic T lymphocytes (CTL) reactive against self-MHC
class I were assessed using a variety of gene-targeted mice. The creation of mice doubly
deficient for perforin and β2μ (B6. Po. β2μo) enabled the determination that perforin was …
histocompatability (MHC) class I-deficient tumor grafts was examined with a view to
determining residual cytotoxic activities that exist in these mice. In particular, the cytotoxic
activities of NK cells and CD8+ cytotoxic T lymphocytes (CTL) reactive against self-MHC
class I were assessed using a variety of gene-targeted mice. The creation of mice doubly
deficient for perforin and β2μ (B6. Po. β2μo) enabled the determination that perforin was …
