[HTML][HTML] Association of p75NTR with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae
TR Bilderback, RJ Grigsby, RT Dobrowsky - Journal of Biological Chemistry, 1997 - ASBMB
Caveolae are plasma membrane microdomains that are enriched in caveolin, the structural
protein of caveolae, sphingomyelin, and other signaling molecules. We previously
suggested that neurotrophin-induced p75 NTR-dependent sphingomyelin hydrolysis may be
localized to the plasma membrane. Therefore, we examined if caveolae were a major site of
p75 NTR-dependent sphingomyelin hydrolysis in p75 NTR-NIH 3T3 fibroblasts. Caveolin-
enriched membranes (CEMs) were prepared by either detergent or detergent-free extraction …
protein of caveolae, sphingomyelin, and other signaling molecules. We previously
suggested that neurotrophin-induced p75 NTR-dependent sphingomyelin hydrolysis may be
localized to the plasma membrane. Therefore, we examined if caveolae were a major site of
p75 NTR-dependent sphingomyelin hydrolysis in p75 NTR-NIH 3T3 fibroblasts. Caveolin-
enriched membranes (CEMs) were prepared by either detergent or detergent-free extraction …
