Two 7α‐hydroxylase enzymes in bile acid biosynthesis
M Schwarz, EG Lund, DW Russell - Current opinion in lipidology, 1998 - journals.lww.com
M Schwarz, EG Lund, DW Russell
Current opinion in lipidology, 1998•journals.lww.comThe addition of a 7‐hydroxyl group is an early and often rate‐limiting step in the synthesis of
bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as
cholesterol 7α‐hydroxylase and oxysterol 7α‐hydroxylase. cDNAs encoding these proteins
have been isolated and used to define two evolutionarily conserved pathways that produce
7α‐hydroxylated bile acids. Curr Opin Lipidol 9: 113–118.© 1998 Rapid Science Ltd
bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as
cholesterol 7α‐hydroxylase and oxysterol 7α‐hydroxylase. cDNAs encoding these proteins
have been isolated and used to define two evolutionarily conserved pathways that produce
7α‐hydroxylated bile acids. Curr Opin Lipidol 9: 113–118.© 1998 Rapid Science Ltd
Abstract
The addition of a 7‐hydroxyl group is an early and often rate‐limiting step in the synthesis of bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as cholesterol 7α‐hydroxylase and oxysterol 7α‐hydroxylase. cDNAs encoding these proteins have been isolated and used to define two evolutionarily conserved pathways that produce 7α‐hydroxylated bile acids. Curr Opin Lipidol 9: 113–118.© 1998 Rapid Science Ltd
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