[HTML][HTML] Transcriptional repression by thyroid hormone receptors: a role for receptor homodimers in the recruitment of SMRT corepressor
SM Yoh, ML Privalsky - Journal of biological chemistry, 2001 - ASBMB
Nuclear hormone receptors, such as the thyroid hormone receptors (T3Rs) and retinoid X
receptors (RXRs), are ligand-regulated transcription factors that control key aspects of
metazoan gene expression. T3Rs can bind to DNA either as receptor homodimers or as
heterodimers with RXRs. Once bound to DNA, nuclear hormone receptors regulate target
gene expression by recruiting auxiliary proteins, denoted corepressors and coactivators. We
report here that T3R homodimers assembled on DNA exhibit particularly strong interactions …
receptors (RXRs), are ligand-regulated transcription factors that control key aspects of
metazoan gene expression. T3Rs can bind to DNA either as receptor homodimers or as
heterodimers with RXRs. Once bound to DNA, nuclear hormone receptors regulate target
gene expression by recruiting auxiliary proteins, denoted corepressors and coactivators. We
report here that T3R homodimers assembled on DNA exhibit particularly strong interactions …
